Key result
PPARgamma 12Ala allele is linked to ~28% lower type 2 diabetes risk versus noncarriers.
Why the study?
Does the presence of the PPARgamma variant 12Ala allele reduce the risk of incident type 2 diabetes in participants of the Nurses' Health Study?
Case-Control (n=1,158)
Does the presence of the PPARgamma variant 12Ala allele reduce the risk of incident type 2 diabetes in participants of the Nurses' Health Study?
Odds Ratio: 0.72 (95% CI 0.52–0.99)
The PPARgamma variant 12Ala allele is associated with a significantly reduced risk of developing type 2 diabetes.
Supports further genetic research on T2D susceptibility; does not support clinical testing or practice change.
OBJECTIVE: To determine whether the Pro12Ala polymorphism in the PPARgamma gene was associated with risk of type 2 diabetes in the Nurses' Health Study. RESEARCH DESIGN AND METHODS: The study was a nested case-control study of 387 incident cases of type 2 diabetes and 771 matching control subjects nested within the Nurses' Health Study, a prospective cohort study. Association between PPARgamma genotype and incident type 2 diabetes was estimated using logistic regression. RESULTS: Carriers of the PPARgamma variant 12Ala allele had reduced risk of type 2 diabetes compared with noncarriers. Unadjusted and adjusted odds ratios of type 2 diabetes were 0.74 (95% CI 0.55-1.00) and 0.72 (0.52-0.99), respectively. CONCLUSIONS: The results of this study provide further support for an inverse association between the PPARgamma variant 12Ala allele and risk of type 2 diabetes.
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Memişoğlu et al. (2003) conducted a case-control in Type 2 diabetes (n=1,158). PPARgamma variant 12Ala allele vs. Noncarriers was evaluated on Incident type 2 diabetes (adjusted OR 0.72, 95% CI 0.52-0.99). Carriers of the PPARgamma variant 12Ala allele had a reduced risk of type 2 diabetes compared with noncarriers (adjusted OR 0.72; 95% CI 0.52-0.99).
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