Key result
The variant Ala isoform of the PPARgamma gene was significantly less frequent in women with PCOS compared to healthy controls (12.6% vs 19.1%; OR 0.609, 95% CI 0.374-0.991, P=0.045).
Why the study?
Is the Pro12 Ala polymorphism of the PPARgamma gene associated with the pathogenesis of polycystic ovary syndrome?
Case-Control (n=250)
Is the Pro12 Ala polymorphism of the PPARgamma gene associated with the pathogenesis of polycystic ovary syndrome?
Answers are grounded in this paper and cite their sources.
The Ala isoform of the PPARgamma gene Pro12 Ala polymorphism appears to be protective against the development of polycystic ovary syndrome.
BACKGROUND: In view of the strong evidence implicating peroxisome proliferator-activated receptor-gamma (PPARgamma) in adiposity and insulin resistance a study was carried out to investigate PPARgamma genotype frequencies in women with polycystic ovary syndrome (PCOS) and to elucidate its role in the pathogenesis of the syndrome. METHODS: The study involved 135 women with PCOS and 115 healthy control women who were genotyped for a known functional variant of the PPARgamma gene using single strand conformation polymorphism (SSCP) analysis. RESULTS: A significantly different allele distribution of the Pro12 Ala polymorphism of the PPARgamma gene was observed between the two groups, with the frequency of the variant Ala isoform being significantly reduced in the PCOS group (12.6%) when compared with the control group (19.1%) (P = 0.045), at an odds ratio of 0.609 (95% confidence interval: 0.374-0.991). The genotype distributions of the Pro12 Ala polymorphism in the PCOS and control groups were different with borderline significance (P = 0.051). CONCLUSIONS: Our data support a role for PPARgamma gene polymorphism in the pathogenesis of PCOS, the presence of the Ala isoform being protective against the development of PCOS.
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Seija Korhonen (2003) conducted a case-control in Polycystic ovary syndrome (PCOS) (n=250). Variant Ala isoform of the PPARgamma gene vs. Healthy controls was evaluated on Frequency of the variant Ala isoform (OR 0.609, 95% CI 0.374-0.991, p=0.045). The variant Ala isoform of the PPARgamma gene was significantly less frequent in women with PCOS compared to healthy controls (12.6% vs 19.1%; OR 0.609, 95% CI 0.374-0.991, P=0.045).
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