Key result
PPAR-γ gene polymorphisms did not significantly affect the risk for PCOS, although specific alleles were associated with reduced testosterone and increased fasting glucose levels.
Why the study?
Are PPAR-γ and PPAR-δ gene polymorphisms associated with the risk and clinical characteristics of polycystic ovary syndrome?
Case-Control (n=331)
Are PPAR-γ and PPAR-δ gene polymorphisms associated with the risk and clinical characteristics of polycystic ovary syndrome?
PPAR-γ and PPAR-δ gene polymorphisms do not appear to increase the risk of PCOS, but specific alleles are associated with altered testosterone and fasting glucose levels.
The aim of the study was to examine the frequency and relationship of peroxisome proliferator-activated receptor (PPAR)-γ and PPAR-δ gene polymorphisms to polycystic ovary syndrome (PCOS) characteristics. We conducted a case-control study protocol, which included 183 PCOS women and 148 healthy volunteers. Genetic, clinical, hormonal, and metabolic characteristics of PCOS patients and controls were estimated and compared. Genotype and allele frequencies did not differ significantly. The Pro(12) Ala polymorphism in exon 2 of the PPAR-γ gene was found in low frequency. Regarding the polymorphism in exon 6, the T-allele carrier PCOS women had significantly lower total testosterone levels. Regarding the +294T/C polymorphism in the exon 4 of the PPAR-δ gene, the C-allele carrier PCOS women had significantly higher fasting glucose levels. In conclusion, the PPAR-γ gene polymorphisms do not appear to affect the risk for PCOS, except for the reduced testosterone levels. The +294T/C polymorphism in the exon 4 of the PPAR-δ gene seems to cause an increase in fasting glucose levels.
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CHRISTOPOULOS et al. (2010) conducted a case-control in Polycystic ovary syndrome (PCOS) (n=331). PPAR-γ and PPAR-δ gene polymorphisms vs. Healthy volunteers (or non-carriers) was evaluated on Genotype and allele frequencies (risk for PCOS). PPAR-γ gene polymorphisms did not significantly affect the risk for PCOS, although specific alleles were associated with reduced testosterone and increased fasting glucose levels.
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