Key result
PPAR gamma Pro/Pro genotype frequency does not differ between women with PCOS and healthy controls.
Why the study?
Is the Pro12Ala polymorphism in the PPAR gamma gene associated with polycystic ovary syndrome in a South Indian population?
Case-Control (n=150)
Is the Pro12Ala polymorphism in the PPAR gamma gene associated with polycystic ovary syndrome in a South Indian population?
The study reports a statistical difference in the distribution of the PPAR gamma Pro12Ala polymorphism between PCOS patients and controls in a South Indian population, suggesting it may be a susceptibility gene.
Answers are grounded in this paper and cite their sources.
No association in this South Indian case-control study; leaves open any role for PPAR gamma Pro12Ala in PCOS susceptibility.
To investigate the frequency of Pro12Ala polymorphism in PPAR gamma gene among PCOS of South Indian Population. Understanding this polymorphism may help us in better diagnosis prevention and therapeutic approaches towards management of PCOS. A total of 75 women with the diagnosis of PCOS and 75 healthy controls were included in this study. The Pro12Ala variant in the PPAR gamma gene was analysed by PCR-RFLP. Genotypic frequencies for PPAR gamma gene Pro12Ala polymorphism showed the frequency of Pro/Pro genotypes was 77% in PCOS and 81% in controls. The odds ratio was 0.71 (95% CI 0.31–1.63) and 2.66 (95% CI 0.21–32.9) and alleles expressed 0.87 (95% CI 0.42–1.79). Regarding hormone levels, there were significant differences between PCOS and non PCOS. PPARγ2 gene Pro12Ala polymorphism was supposed to be susceptible genes in PCOS. The present study demonstrated that there is a statistical difference between the distributions of PPAR gamma Pro12Ala polymorphism in South Indian Population.
No takes yet. Share an insight, caveat, or question.
Jacob et al. (2016) conducted a case-control in Polycystic ovary syndrome (PCOS) (n=150). PPAR gamma gene Pro12Ala polymorphism vs. Healthy controls was evaluated on Pro/Pro genotype frequency (OR 0.71, 95% CI 0.31-1.63). The frequency of the Pro/Pro genotype of the PPAR gamma gene Pro12Ala polymorphism was 77% in women with PCOS and 81% in healthy controls (OR 0.71; 95% CI 0.31-1.63).
Synapse has enriched 10 related papers. Consider them for comparative context: