Key result
PPARγ Pro12Ala genotype linked to ~3-fold higher PCOS risk and elevated triglycerides.
Why the study?
Are PPARγ Pro12Ala and C161T polymorphisms associated with the risk of polycystic ovary syndrome and altered lipid profiles?
Cross-Sectional (n=283)
No
Are PPARγ Pro12Ala and C161T polymorphisms associated with the risk of polycystic ovary syndrome and altered lipid profiles?
The PPARγ Pro12Ala polymorphism is associated with an increased risk of PCOS and altered lipid profiles, whereas the C161T polymorphism is not significantly associated with PCOS risk.
Answers are grounded in this paper and cite their sources.
May support hypothesis generation on PPARγ in PCOS; should not yet change clinical risk assessment or lipid management.
BACKGROUND: The aim of present study was to clarify the role of the peroxisome proliferator-activated receptor (PPAR) γ Pro12Ala and C161T polymorphisms in the pathogenesis of polycystic ovary syndrome (PCOS) and their influence on lipid and lipoprotein profiles of patients. MATERIALS AND METHODS: The present cross-sectional study consisted of 50 women with PCOS, who referred to the Kermanshah University of Medical Sciences Clinic between April and October 2015, and 233 unrelated age-matched healthy women from the same region (West Iran). The PPARγ Pro12Ala and PPARγ C161T polymorphisms were genotyped using the polymerase chain reaction-restriction fragment length polymorphism method. Fasting blood sugar (FBS), serum triglycerides (TG), cholesterol, low density lipoprotein- cholesterol (LDL-C), high density lipoproteincholesterol (HDL-C) and estradiol levels were measured. RESULTS: The serum level of estradiol was significantly lower in PCOS patients compared to healthy women. The PPARγ Pro12Ala (CG) genotype increased the risk of PCOS 2.96-fold. The frequency of the PPARγ T allele (at C161T) was 21% in patients and 17.2% in controls with no significant difference (P=0.52). In all studied individuals, the PPARγ CG genotype was associated with significantly higher levels of TG. However, significantly lower levels of total cholesterol and LDL-C were observed in PPARγ TT individuals compared with those with the CC genotype. Within the PCOS group, the PPARγ CG genotype was significantly associated with lower levels of estradiol compared with the CC genotype. Also, the CG genotype was significantly associated with higher levels of TG when compared with the CC genotype. CONCLUSION: Our study shows that, unlike PPARγ C161T, PPARγ Pro12Ala is associated with the risk of PCOS. Also, we found that the lipid and lipoprotein profiles significantly vary based on PPARγ Pro12Ala and C161T genotypes.
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Rahimi et al. (2018) conducted a cross-sectional in Polycystic ovary syndrome (PCOS) (n=283). PPARγ Pro12Ala and C161T polymorphisms vs. Healthy women / wild-type genotypes was evaluated on Risk of PCOS associated with PPARγ Pro12Ala (CG) genotype (2.96-fold increased risk). The PPARγ Pro12Ala (CG) genotype was associated with a 2.96-fold increased risk of PCOS and higher triglyceride levels, whereas the C161T polymorphism showed no significant association with PCOS.
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