The synthesis of 2,2',St,2"-terthienyl (IV) is reported.A key intermediate in this synthesis was 1,4-di(2-thieny1)-l,4-butanedione (III), which was c prepared from trimethylsilyl en01 ether (11) of 2-acetylthiophene (I).Corresponding fury1 derivatives were also synthesized by the similar procedure.Since 2,2',St,2"-terthienyl (IV) was isolated from Tagestes plants1, considerable attention have been given to synthesize it and some methods have been reported in literatures2, because of its high nematicidal activity against nematodes such as Ditylenchus dipsaci and Heterodea rostochiensh . 3However those methods are laborious and/or the yields are not satisfactory.In this paper, we wish to report a simple synthesis of IV from commercially available 2-acetylthiophen (I) in three steps.
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Asano et al. (1977) studied this question.