Key result
Atenolol pretreatment linked to 0% incidence of myocardial ischemia during anesthesia versus untreated patients.
Why the study?
Does pretreatment with atenolol prevent myocardial ischaemia during anaesthesia in hypertensive patients?
Population
90 hypertensive patients undergoing anaesthesia and surgery
Comparison
Atenolol or diuretic therapy vs Untreated hypertensive patients
Design
Cohort
Follow-up
During anaesthesia and surgery
Authors
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May support atenolol pretreatment to avert perioperative ischaemia in hypertensives; hypothesis-generating and requires randomized confirmation.
Observational (n=90)
Does pretreatment with atenolol prevent myocardial ischaemia during anaesthesia in hypertensive patients?
Absolute Event Rate: 0% vs 28.2%
Pretreatment with atenolol, but not diuretics, provides prophylaxis against myocardial ischaemia during anaesthesia in hypertensive patients.
Stone et al. (1988) conducted an observational in Hypertension (n=90). Atenolol vs. Untreated or diuretic therapy was evaluated on Myocardial ischaemia during anaesthesia and surgery. Pretreatment with atenolol prevented myocardial ischaemia during anaesthesia (0 of 44 patients), compared to 28.2% of untreated patients and 57.1% of those receiving diuretics.
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