Key result
Low-dose acetylcholine strongly inhibits pacemaker current in isolated SA node cells, acting beyond K-current activation.
Population
Isolated sino-atrial node cells
Design
Preclinical
Authors
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Challenges K-current-only mechanism of acetylcholine bradycardia in isolated SAN cells; leaves open in vivo or clinical translation.
The slowing of cardiac pacemaker activity by acetylcholine is mediated by a strong inhibitory action on the pacemaker current (if), challenging the view that it is solely due to K-current activation.
Dario DiFrancesco (1987) studied this question. Acetylcholine was evaluated. Low doses of acetylcholine exert a strong inhibitory action on the pacemaker current (if) in isolated sino-atrial node cells, modifying the view that slowing is solely due to K-current activation.
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