Key result
Azepexole and clonidine both lower BP vs placebo and enhance baroreflex sensitivity.
Why the study?
Do azepexole and clonidine affect baroreceptor mediated reflex bradycardia and physiological tremor in healthy volunteers?
RCT (n=6)
Do azepexole and clonidine affect baroreceptor mediated reflex bradycardia and physiological tremor in healthy volunteers?
p-value: p=<0.05
Both azepexole and clonidine reduce blood pressure and enhance baroreflex sensitivity to phenylephrine in healthy volunteers, though they differ in their effects during the Valsalva maneuver.
Should not alter hypertension management; leaves open azepexole's comparative effects versus clonidine in patients.
The effects of oral administration of azepexole 10 mg, clonidine 300 micrograms and placebo on baroreceptor mediated reflex bradycardia and physiological tremor were investigated in six healthy volunteers. Both azepexole and clonidine reduced (P less than 0.05) systolic (120.5 +/-2.5 to 105.0 +/- 3.3 mm Hg; 115.8 +/- 2.6 to 104.7 +/- 2.8 mm Hg respectively) and diastolic (52.5 +/- 2.6 to 47.2 +/- 1.4 mmHg; 53.7 +/- 1.6 to 49.0 +/- 1.5 mmHg respectively) pressure when compared to placebo and to pre-treatment values. This reduction in pressure was not accompanied by a change in heart rate. Both azepexole and clonidine enhanced (P less than 0.05) baroreflex sensitivity to increases in systolic arterial pressure with phenylephrine. Clonidine facilitated (P less than 0.05) baroreflex sensitivity during the strain phase of the Valsalva manoeuvre, whereas azepexole reduced it (P less than 0.05). Neither clonidine nor azepexole altered finger tremor when compared to placebo or pre-treatment values. Azepexole produced (P less than 0.05) sedation compared to placebo but not when compared to pre-treatment values. Clonidine caused significant increases in sedation when compared to both placebo and to pre-treatment values. The differences between azepexole and clonidine may be due to the greater specificity of azepexole for the alpha 2-adrenoceptor than clonidine.
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Harron et al. (1985) conducted an RCT in Healthy volunteers (n=6). Azepexole and clonidine vs. Placebo was evaluated on Baroreceptor mediated reflex bradycardia and physiological tremor (p=<0.05). Azepexole and clonidine both significantly reduced systolic and diastolic blood pressure compared to placebo (P<0.05) and enhanced baroreflex sensitivity to increases in systolic arterial pressure.
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