March 1, 1988Journal of Hypertension
Comparison of betaxolol with verapamil in hypertensive patients: discrepancy between office and ambulatory blood pressures
Key result
Betaxolol reduces ambulatory daytime BP vs. verapamil, despite both drugs lowering office BP.
- n=17
Why the study?
Does betaxolol compared to verapamil improve office and ambulatory blood pressure in patients with uncomplicated essential hypertension?
Population
17 patients with uncomplicated essential hypertension, aged 35-67 years
Comparison
Betaxolol 20 mg/day for 6 weeks vs Slow-release verapamil 240-480 mg/day for 6 weeks
Design
RCT, Sequence of treatment phases was randomly allocated
Follow-up
6 weeks per treatment phase
Authors
Discussion
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Implication
Betaxolol may be preferred for sustained BP control; challenges reliance on office BP alone as primary endpoint in hypertension RCTs.
Study Design
Type
RCT (n=17)
Randomization
randomly allocated
Structured PICO
Does betaxolol compared to verapamil improve office and ambulatory blood pressure in patients with uncomplicated essential hypertension?
P
Population
17 patients aged 35 to 67 years with uncomplicated essential hypertension treated in a crossover design for two 6-week periods.
I
Intervention
Betaxolol 20 mg/day for 6 weeks
C
Comparator
Slow-release verapamil 240-480 mg/day for 6 weeks (crossover design with 2-week wash-out period)
O
Outcome
Blood pressure lowering effect evaluated at physician's office and by ambulatory daytime blood pressure monitoringsurrogate
Betaxolol significantly reduces both office and ambulatory blood pressure, whereas verapamil only significantly reduces office blood pressure in patients with uncomplicated essential hypertension.
Cite This Study
Waeber et al. (1988) conducted an RCT in uncomplicated essential hypertension (n=17). Betaxolol vs. Verapamil (slow-release formulation, 240-480 mg/day) was evaluated on Office and ambulatory daytime blood pressure. Betaxolol significantly reduced ambulatory daytime blood pressure, whereas verapamil did not, despite both drugs significantly lowering office blood pressure.