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September 28, 2018Biomedicine & PharmacotherapyOpen Access

The promising antitumour drug disulfiram inhibits viability and induces apoptosis in cardiomyocytes

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Key result

Disulfiram inhibited cardiomyocyte viability and promoted apoptosis, with cardiomyocytes demonstrating greater sensitivity to the drug than cancer cells.

Why the study?

Does disulfiram inhibit viability and induce apoptosis in cardiomyocytes?

Population

cardiomyocytes and cancer cells

Design

Preclinical

Authors

YLYanfei LiJSJunwei ShenMFMing Fang

Discussion

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Member takes

Overview

May signal disulfiram cardiotoxicity risk; animal data leave open human relevance and mitigation.

Structured PICO

Does disulfiram inhibit viability and induce apoptosis in cardiomyocytes?

P
Population
cardiomyocytes and cancer cells
I
Intervention
Disulfiram (DSF)
O
Outcome
cardiomyocyte viability, activity, and apoptosissafety

Disulfiram exhibits potential cardiotoxic effects by inhibiting viability and inducing apoptosis in cardiomyocytes, though PEG may serve as a promising solvent to mitigate these adverse effects.

Cite This Study

Li et al. (2018) studied Cardiomyocyte viability and apoptosis. Disulfiram (DSF) vs. Cancer cells was evaluated on Cardiomyocyte viability and apoptosis. Disulfiram inhibited cardiomyocyte viability and promoted apoptosis, with cardiomyocytes demonstrating greater sensitivity to the drug than cancer cells.

synapsesocial.com/papers/6aa666a2bc2c7db7488e5f9ahttps://doi.org/10.1016/j.biopha.2018.09.123
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