What does this research mean for the field?

Percutaneous left atrial appendage closure is safe and effective in reducing ischemic stroke and major bleeding risk, even with a simplified post-procedural antithrombotic regimen in high-risk patients. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 14, 2023International Heart JournalOpen Access

LAAC linked to ~86% lower ischemic stroke risk and reduced major bleeding versus predicted rates.

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Nonvalvular atrial fibrillation (n=136). Intervention: Percutaneous left atrial appendage closure (LAAC) vs. Predicted risk (CHA2DS2-VASc score). Primary outcome: Ischemic stroke or TIA (86% risk reduction).

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Population

Patients undergoing percutaneous LAAC procedures in Gottsegen National Cardiovascular Center

Design

Observational study

Key result

Percutaneous left atrial appendage closure resulted in an 86% relative reduction in ischemic stroke risk and a 37% reduction in major bleeding risk compared to predicted rates.

Authors

AZAnita Zádori ZKZsuzsanna Kis TTTibor Tóth

Discussion

Member takes

Overview

May support LAA closure consideration in AF; leaves open need for randomized confirmation of benefits.

Study Design

Type

Cohort (n=136)

Multicenter

Structured PICO

Population

136 patients with nonvalvular atrial fibrillation and contraindications to long-term oral anticoagulation who underwent percutaneous left atrial appendage closure, followed for a mean of 2.7 years.

Exposure

Percutaneous left atrial appendage closure (LAAC) using various CE-marked devices (Amplatzer Cardiac Plug, Amulet, LAmbre, Watchman, Watchman Flx), followed by individualized antithrombotic therapy (dual or single antiplatelet therapy).

Outcome

Rates of outpatient cardiac mortality, ischemic brain event, and major bleeding, as well as procedural success and periprocedural complications.hard clinical

Main Result

Effect estimate: 86% risk reduction

Absolute Event Rate: 0.8% vs 6%

Percutaneous LAAC is safe and effective in a real-world, high-bleeding-risk population, providing robust stroke risk reduction and allowing for simplified post-procedural antithrombotic regimens.

Limitations

Single-center, nonrandomized, retrospective data collection design
Relatively small sample size
single-center
nonrandomized
retrospective data collection design
relatively small sample size

Cite This Study

Zádori et al. (2023) conducted a cohort in Nonvalvular atrial fibrillation (n=136). Percutaneous left atrial appendage closure (LAAC) vs. Predicted risk (CHA2DS2-VASc score) was evaluated on Ischemic stroke or TIA (86% risk reduction). Percutaneous left atrial appendage closure resulted in an 86% relative reduction in ischemic stroke risk and a 37% reduction in major bleeding risk compared to predicted rates.

synapsesocial.com/papers/6aa6680a22b0548423396f01 https://doi.org/10.1536/ihj.22-639

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March 14, 2023International Heart JournalOpen Access

LAAC linked to ~86% lower ischemic stroke risk and reduced major bleeding versus predicted rates.

View Full Paper

Ask AI

Bookmark

Population

Patients undergoing percutaneous LAAC procedures in Gottsegen National Cardiovascular Center

Design

Observational study

Key result

Percutaneous left atrial appendage closure resulted in an 86% relative reduction in ischemic stroke risk and a 37% reduction in major bleeding risk compared to predicted rates.

Authors

AZAnita Zádori ZKZsuzsanna Kis TTTibor Tóth

Discussion

Member takes

Overview

May support LAA closure consideration in AF; leaves open need for randomized confirmation of benefits.

Study Design

Type

Cohort (n=136)

Multicenter

Structured PICO

Population

136 patients with nonvalvular atrial fibrillation and contraindications to long-term oral anticoagulation who underwent percutaneous left atrial appendage closure, followed for a mean of 2.7 years.

Exposure

Outcome

Rates of outpatient cardiac mortality, ischemic brain event, and major bleeding, as well as procedural success and periprocedural complications.hard clinical

Main Result

Effect estimate: 86% risk reduction

Absolute Event Rate: 0.8% vs 6%

Percutaneous LAAC is safe and effective in a real-world, high-bleeding-risk population, providing robust stroke risk reduction and allowing for simplified post-procedural antithrombotic regimens.

Limitations

Single-center, nonrandomized, retrospective data collection design
Relatively small sample size
single-center
nonrandomized
retrospective data collection design
relatively small sample size

Cite This Study

synapsesocial.com/papers/6aa6680a22b0548423396f01 https://doi.org/10.1536/ihj.22-639

Also Consider

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