Key result
Measuring 3H-ouabain binding yields ~413 pmol/g in postmortem myocardium, demonstrating Na,K-pump quantification feasibility in biopsies.
Population
15 patients aged 64-86 years providing necropsy specimens of the left ventricle
Design
Other
Authors
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Supports biopsy-based Na,K-pump quantification in myocardium; leaves open clinical utility pending validation studies.
Observational (n=20)
The concentration of Na, K-pumps in human myocardium can be reliably determined by measuring 3H-ouabain binding capacity in biopsy or postmortem specimens up to 18 hours after death.
Nørgaard et al. (1986) conducted an observational in Postmortem human myocardium (n=20). 3H-ouabain binding site measurement was evaluated on 3H-ouabain binding site concentration. The mean concentration of 3H-ouabain binding sites in human myocardium 6 hours after death was 413 pmol/g wet weight, demonstrating the feasibility of quantifying Na,K-pumps in biopsy specimens.
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