What question did this study set out to answer?

To determine whether bound fractions or total plasma concentrations drive the variability of biologically active catecholamines in patients undergoing major surgery.

September 1, 1988Scandinavian Journal of Clinical and Laboratory Investigation

Catecholamine binding and concentrations in acute phase plasma after surgery

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Authors

GSG. SagerUiT The Arctic University of Norway TTT.S. TrovikUniversity Hospital of North Norway LSL. Slørdal

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Implication

Observational study finds total plasma concentrations determine active catecholamine levels after surgery, indicating acute phase protein binding shifts play a minor role.

Key Points

To determine whether bound fractions or total plasma concentrations drive the variability of biologically active catecholamines in patients undergoing major surgery.
Measured plasma binding and total concentrations of noradrenaline and adrenaline before and up to 5 days after major hip surgery in 5 subjects.
Assessed surgical acute phase response by tracking plasma concentrations of albumin and alpha-1 acid glycoprotein.
Plasma protein binding increased from pre-surgery baselines of 23.0% for noradrenaline and 18.4% for adrenaline to 30.9% and 24.0%, respectively, at post-operative day 5.
Surgical trauma induced an acute phase reaction characterized by decreased albumin levels and elevated alpha-1 acid glycoprotein levels.
Variability in biologically active catecholamine concentrations was primarily governed by total plasma concentrations rather than changes in protein binding.

Cite This Study

Sager et al. (1988) studied this question.

synapsesocial.com/papers/6aa675787b142bbe3664d05c https://doi.org/10.3109/00365518809085751

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Implication

Observational study finds total plasma concentrations determine active catecholamine levels after surgery, indicating acute phase protein binding shifts play a minor role.

Catecholamine binding and concentrations in acute phase plasma after surgery

Discussion

Member takes

Implication

Key Points

Cite This Study

Catecholamine binding and concentrations in acute phase plasma after surgery

Discussion

Member takes

Implication

Key Points

Cite This Study

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