What question did this study set out to answer?

To evaluate perioperative changes in plasma cyclic AMP, adrenaline, and noradrenaline concentrations during and after surgery of moderate severity.

March 1, 1978British journal of surgery

Cyclic AMP, adrenaline and noradrenaline in plasma during surgery

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Why the study?

Does surgery (hysterectomy) alter plasma concentrations of cyclic AMP, adrenaline, and noradrenaline?

Population

6 patients undergoing hysterectomy

Comparison

Observation during surgery and early… vs Baseline (before induction of anaesthesia)

Design

Cohort

Follow-up

6 h after skin incision

Authors

SMS. Nistrup MadsenFrederiksberg Hospital FFF. Fog‐MøllerSankt Hans Hospital CCC. ChristiansenUniversity of Copenhagen

Discussion

Member takes

Implication

Highlights potential adrenaline-cyclic AMP link in postoperative stress; leaves open clinical relevance pending larger prospective studies.

Key Points

To evaluate perioperative changes in plasma cyclic AMP, adrenaline, and noradrenaline concentrations during and after surgery of moderate severity.
Measured plasma concentrations of cyclic AMP, adrenaline, and noradrenaline in 6 patients undergoing hysterectomy.
Collected blood samples from before the induction of anaesthesia up to 6 hours after skin incision.
Plasma cyclic AMP and adrenaline concentrations increased after skin incision and peaked in the early postoperative phase, whereas noradrenaline levels did not change significantly.
Plasma cyclic AMP and adrenaline levels showed a strong positive correlation (r = 0.84, P < 0.01).

Structured PICO

Does surgery (hysterectomy) alter plasma concentrations of cyclic AMP, adrenaline, and noradrenaline?

Population

6 patients undergoing hysterectomy

Intervention

Observation during surgery (hysterectomy) and early postoperative phase

Comparator

Baseline (before induction of anaesthesia)

Outcome

Plasma concentrations of cyclic AMP, adrenaline and noradrenalinesurrogate

The most pronounced acute endocrine stress response to moderate surgery occurs after termination of anaesthesia, driven by adrenaline increasing cyclic AMP.

Cite This Study

Madsen et al. (1978) studied this question.

synapsesocial.com/papers/6a76b8152e130d02afec2615 https://doi.org/10.1002/bjs.1800650315

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Implication

Highlights potential adrenaline-cyclic AMP link in postoperative stress; leaves open clinical relevance pending larger prospective studies.

Cyclic AMP, adrenaline and noradrenaline in plasma during surgery

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Cyclic AMP, adrenaline and noradrenaline in plasma during surgery

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider