Key result
Aspirin resistance evaluation techniques, etiology, epidemiology, and molecular genetic aspects were reviewed to provide recommendations for overcoming tolerance in ischemic stroke prevention.
This review summarizes the etiology, epidemiology, evaluation techniques, and molecular genetics of aspirin resistance, providing recommendations for overcoming tolerance in ischemic stroke prevention.
Aspirin resistance testing may guide stroke prevention strategies; leaves open efficacy of tailored regimens pending trials.
The article discusses the issues related to the personalization of preventive measures for ischemic stroke, in particular those associated with resistance to one of the most common antiplatelet drugs, aspirin. A brief historical note on investigation of acetylsalicylic acid is provided. The paper addresses the issue of etiological factors and epidemiology of aspirin resistance. An analysis and comparison of various techniques for evaluation of this phenomenon are performed. Separately, a molecular genetic aspect of the pathology is considered. In conclusion, the recommendations for overcoming tolerance to aspirin therapy are provided.
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Tanashyan et al. (2017) conducted a review in Ischemic stroke / Aspirin resistance. Aspirin was evaluated. Aspirin resistance evaluation techniques, etiology, epidemiology, and molecular genetic aspects were reviewed to provide recommendations for overcoming tolerance in ischemic stroke prevention.
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