Key result
Laser-Doppler flowmetry detects a ~62% lower area of hyperemia in CAD patients versus healthy controls.
Why the study?
Does the area of hyperemia measured by Laser-Doppler flowmetry accurately discriminate between patients with coronary artery disease and healthy controls?
Population
100 individuals, comprising 40 patients with proven coronary artery disease (CAD) and 60 healthy controls.
Comparison
Measurement of postocclusive hyperemic response… vs Healthy controls.
Design
Case-control
Authors
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Suggests Laser-Doppler flowmetry detects endothelial dysfunction in CAD; hypothesis-generating and should not yet alter clinical practice.
Case-Control (n=100)
Does the area of hyperemia measured by Laser-Doppler flowmetry accurately discriminate between patients with coronary artery disease and healthy controls?
Absolute Event Rate: 754.9% vs 1981.3%
p-value: p=<0.001
The area of hyperemia measured by Laser-Doppler flowmetry is a highly sensitive and specific noninvasive parameter for identifying endothelial dysfunction in patients with coronary artery disease.
Stiefel et al. (2011) conducted a case-control in Coronary artery disease (n=100). Coronary artery disease (CAD) vs. Healthy controls was evaluated on Area of hyperemia (perfusion units per second) (p=<0.001). The area of hyperemia measured by Laser-Doppler flowmetry was significantly lower in CAD patients than healthy controls (754.9 vs 1981.3 perfusion units per second, P<0.001).
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