Key result
Colon distension in dogs reflexly increases heart rate, blood pressure, and LV inotropy via sympathetic nerves.
Why the study?
Does distension of the descending colon affect heart rate, arterial blood pressure, or left ventricular inotropic state in anaesthetized dogs?
Population
26 dogs, anaesthetized with sodium pentobarbitone and artificially ventilated
Design
Preclinical
Authors
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Establishes a colo-cardiac sympathetic reflex in anaesthetized dogs; leaves open translation to human physiology or clinical relevance.
Does distension of the descending colon affect heart rate, arterial blood pressure, or left ventricular inotropic state in anaesthetized dogs?
Distension of the descending colon in dogs causes reflex increases in heart rate, blood pressure, and left ventricular contractility via sympathetic pathways involving hypogastric nerves.
Cevese et al. (1992) studied this question. Distension of the descending colon was evaluated on Heart rate, arterial blood pressure, and left ventricular inotropic state. Distension of the descending colon in anaesthetized dogs reflexly increased heart rate, arterial blood pressure, and left ventricular inotropic state via sympathetic effects and hypogastric nerves.
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