Key result
Inappropriate LV mass in hypertension links to delayed relaxation, mild systolic dysfunction, and increased myocardial stiffness.
Why the study?
Is inappropriate left ventricular mass associated with systolic and diastolic dysfunction in hypertensive patients without prevalent cardiovascular disease?
Population
1513 hypertensive participants from the HyperGEN population who were without prevalent cardiovascular disease.
Comparison
Inappropriate left ventricular mass vs Appropriate left ventricular mass
Design
Cross-sectional
Authors
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May flag subclinical LV impairment in hypertension; hypothesis-generating and should not yet change practice.
Cross-Sectional (n=1,513)
Is inappropriate left ventricular mass associated with systolic and diastolic dysfunction in hypertensive patients without prevalent cardiovascular disease?
p-value: p=≤0.001
Inappropriate left ventricular mass in hypertensive patients is associated with delayed LV relaxation and mild systolic dysfunction, serving as a marker for increased myocardial stiffness.
KITZMAN et al. (2004) conducted a cross-sectional in Hypertension (n=1,513). Inappropriate left ventricular mass vs. Appropriate left ventricular mass was evaluated on LV dimensions, relative wall thickness, ejection fraction, midwall shortening, cardiac output, and isovolumic relaxation time (IVRT) (p=≤0.001). Inappropriate left ventricular mass in hypertensive patients was associated with delayed LV relaxation, mild systolic dysfunction, and increased myocardial stiffness (P≤0.001).
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