What is the clinical evidence from this study?

Study design: Review. Population: Acute disseminated encephalomyelitis (ADEM).

What does this research mean for the field?

Standardization of prospective, multicenter study designs is critically required to define acute disseminated encephalomyelitis and distinguish it from multiple sclerosis at first presentation in children. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 16, 2004Current Opinion in Pediatrics

Toward the definition of acute disseminated encephalitis of childhood

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Key result

Standardized prospective studies remain essential to define ADEM and distinguish it from childhood MS.

Population

Children and adolescents with acute disseminated encephalomyelitis (ADEM) or multiple sclerosis

Design

Review

Authors

GAGülay Alper NSNina F. Schor

Discussion

Member takes

Overview

Diagnostic uncertainty risks misdirected therapy in children; leaves open whether standardized prospective multicenter studies will refine ADEM-MS distinctions.

Structured PICO

Population

Children and adolescents with acute disseminated encephalomyelitis (ADEM) or multiple sclerosis

Outcome

Definition of ADEM and its distinction from childhood multiple sclerosis

Standardization of prospective, multicenter studies is required to define ADEM and distinguish it from childhood multiple sclerosis to guide appropriate preventive therapies.

Limitations

All studies to date aimed at differential characterization of ADEM and childhood multiple sclerosis have been retrospective case reviews.
All studies to date aimed at differential characterization of ADEM and childhood multiple sclerosis have been retrospective case reviews
Each study has examined a different array of characteristics of a differently defined patient population

Cite This Study

Alper et al. (2004) conducted a review in Acute disseminated encephalomyelitis (ADEM). Standardization of prospective, multicenter study design is critically needed to define acute disseminated encephalomyelitis and distinguish it from childhood multiple sclerosis.

synapsesocial.com/papers/6aa67e8c5becb0bc28eed920 https://doi.org/10.1097/01.mop.0000136120.83277.72

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November 16, 2004Current Opinion in Pediatrics

Toward the definition of acute disseminated encephalitis of childhood

View Full Paper

Ask AI

Bookmark

Key result

Standardized prospective studies remain essential to define ADEM and distinguish it from childhood MS.

Population

Children and adolescents with acute disseminated encephalomyelitis (ADEM) or multiple sclerosis

Design

Review

Authors

GAGülay Alper NSNina F. Schor

Discussion

Member takes

Overview

Diagnostic uncertainty risks misdirected therapy in children; leaves open whether standardized prospective multicenter studies will refine ADEM-MS distinctions.

Structured PICO

Population

Children and adolescents with acute disseminated encephalomyelitis (ADEM) or multiple sclerosis

Outcome

Definition of ADEM and its distinction from childhood multiple sclerosis

Standardization of prospective, multicenter studies is required to define ADEM and distinguish it from childhood multiple sclerosis to guide appropriate preventive therapies.

Limitations

All studies to date aimed at differential characterization of ADEM and childhood multiple sclerosis have been retrospective case reviews.
All studies to date aimed at differential characterization of ADEM and childhood multiple sclerosis have been retrospective case reviews
Each study has examined a different array of characteristics of a differently defined patient population

Cite This Study

synapsesocial.com/papers/6aa67e8c5becb0bc28eed920 https://doi.org/10.1097/01.mop.0000136120.83277.72

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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