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April 1, 2006Neurological Research

The clinical course of acute disseminated encephalomyelitis

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Population

Pediatric and adult patients with acute disseminated encephalomyelitis (ADEM)

Design

Review

Authors

DWDean M. Wingerchuk

Discussion

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Overview

May warrant cautious long-term monitoring after ADEM; leaves open standardized prospective studies to refine conversion risks.

Structured PICO

P
Population
Pediatric and adult patients with acute disseminated encephalomyelitis (ADEM)
O
Outcome
Risk of relapse and conversion to multiple sclerosis (MS)

ADEM carries a substantial risk of conversion to multiple sclerosis in both children and adults, highlighting the need for cautious diagnosis of monophasic ADEM and standardized prospective studies.

Limitations

  • Lack of prospective studies
  • Lack of specific and reproducible clinical case definitions
  • Variable follow-up methods

Cite This Study

Dean M. Wingerchuk (2006) studied this question.

synapsesocial.com/papers/6a8a5422d33e374d11558cd7https://doi.org/10.1179/016164106x98251
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Acute disseminated encephalomyelitis: A follow-up study of 40 adult patients2001 · 513 citations
  2. 2Clinical and neuroradiologic features of acute disseminated encephalomyelitis in children2001 · 541 citations
  3. 3Acute Disseminated Encephalomyelitis in Children2002 · 354 citations
  4. 4Acute disseminated encephalomyelitis, multiphasic disseminated encephalomyelitis and multiple sclerosis in children2000 · 703 citations
  5. 5Recurrence of Acute Disseminated Encephalomyelitis at the Previously Affected Brain Site2001 · 81 citations