What does this research mean for the field?

Inducing acute myocardial ischemia via retrograde blood flow in dogs significantly reduces collateral myocardial blood flow and increases the incidence of ventricular tachycardia compared to standard coronary occlusion. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1991Japanese Circulation Journal-english EditionOpen Access

Myocardial blood flow, alternans of ST segment elevation, conduction delay and ventricular arrhythmia during acute myocardial ischemia with and without retrograde blood flow in canine hearts.

Q: What are the key findings of this study?

Inducing ischemia via retrograde blood flow in dogs resulted in a significantly higher incidence of ventricular tachycardia compared to LAD occlusion (79% vs 41%, p<0.01).

Q: What is the clinical evidence from this study?

Study design: Other. Population: Acute myocardial ischemia (n=60). Intervention: Retrograde blood flow technique vs. Left anterior descending coronary artery occlusion. Primary outcome: Incidence of ventricular tachycardia (p=<0.01).

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Key result

Ischemia via retrograde blood flow in dogs increases VT incidence by ~93% versus LAD occlusion.

P<0.01
n=60

Authors

YNYasuo NagamotoUniversity of Occupational and Environmental Health Japan MFMasasuke FujitaUniversity of Occupational and Environmental Health Japan YFYouichiro Furuno

Discussion

Member takes

Implication

Raises possibility of greater arrhythmogenicity with retrograde ischemia in models; leaves open relevance to human coronary syndromes.

PICO

Population

60 dogs subjected to acute myocardial ischemia induced by either LAD occlusion or retrograde blood flow for 10 minutes.

Intervention / Comparator

Retrograde blood flow technique vs Left anterior descending coronary artery occlusion

Primary Outcome

Incidence of ventricular tachycardia, p=<0.01

Main Result

Absolute Event Rate: 79% vs 41%

p-value: p=<0.01

Cite This Study

Nagamoto et al. (1991) studied Acute myocardial ischemia (n=60). Retrograde blood flow technique vs. Left anterior descending coronary artery occlusion was evaluated on Incidence of ventricular tachycardia (p=<0.01). Inducing ischemia via retrograde blood flow in dogs resulted in a significantly higher incidence of ventricular tachycardia compared to LAD occlusion (79% vs 41%, p<0.01).

synapsesocial.com/papers/6aa68184246eab12a27f50eb https://doi.org/10.1253/jcj.55.581

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