What does this research mean for the field?

Intravenous 2% dodecafluoropentane emulsion is superior to sonicated human albumin for left ventricular cavity opacification and endocardial border delineation in patients with suboptimal echocardiograms while maintaining a similar safety profile. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 1, 1998Journal of the American College of CardiologyOpen Access

Phase III multicenter trial comparing the efficacy of 2% dodecafluoropentane emulsion (EchoGen) and sonicated 5% human albumin (Albunex) as ultrasound contrast agents in patients with suboptimal echocardiograms

Q: What are the key findings of this study?

Intravenous 2% dodecafluoropentane emulsion was superior to sonicated human albumin for full or intermediate LV cavity opacification (83% vs. 55% for investigators, p<0.0001).

Q: What is the clinical evidence from this study?

Study design: RCT. Population: Suboptimal echocardiograms (n=254). Intervention: 2% dodecafluoropentane (DDFP) emulsion (EchoGen) vs. Sonicated 5% human albumin (Albunex). Primary outcome: Full or intermediate LV cavity opacification (investigators) (p=<0.0001).

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Key result

Intravenous 2% dodecafluoropentane emulsion increases LV cavity opacification by ~51% vs sonicated human albumin.

P<0.0001
n=254

Why the study?

Does intravenous 2% dodecafluoropentane emulsion improve left ventricular cavity opacification compared to sonicated human albumin in adult patients with suboptimal echocardiograms?

Study Design

Type

RCT (n=254)

Blinding

Single-blind

Multicenter

Yes

Structured PICO

Does intravenous 2% dodecafluoropentane emulsion improve left ventricular cavity opacification compared to sonicated human albumin in adult patients with suboptimal echocardiograms?

Population

254 adult patients with suboptimal echocardiograms who received sequential injections of contrast agents to evaluate left ventricular cavity opacification.

Intervention

Intravenous 2% dodecafluoropentane (DDFP) emulsion

Comparator

Intravenous sonicated 5% human albumin (active control)

Outcome

Left ventricular (LV) cavity opacificationsurrogate

Main Result

Absolute Event Rate: 83% vs 55%

p-value: p=<0.0001

Intravenous 2% dodecafluoropentane emulsion is superior to sonicated human albumin for left ventricular cavity opacification and endocardial border definition in patients with suboptimal echocardiograms, with a similar safety profile.

Discussion

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Implication

May improve LV visualization in suboptimal echocardiograms; extends contrast options pending outcome trials.

Cite This Study

Grayburn et al. (1998) conducted an RCT in Suboptimal echocardiograms (n=254). 2% dodecafluoropentane (DDFP) emulsion (EchoGen) vs. Sonicated 5% human albumin (Albunex) was evaluated on Full or intermediate LV cavity opacification (investigators) (p=<0.0001). Intravenous 2% dodecafluoropentane emulsion was superior to sonicated human albumin for full or intermediate LV cavity opacification (83% vs. 55% for investigators, p<0.0001).

synapsesocial.com/papers/6aa690c166012019823a600d https://doi.org/10.1016/s0735-1097(98)00219-8

Topics

Echocardiography

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Phase III multicenter trial comparing the efficacy of 2% dodecafluoropentane emulsion (EchoGen) and sonicated 5% human albumin (Albunex) as ultrasound contrast agents in patients with suboptimal echocardiograms

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Topics

Phase III multicenter trial comparing the efficacy of 2% dodecafluoropentane emulsion (EchoGen) and sonicated 5% human albumin (Albunex) as ultrasound contrast agents in patients with suboptimal echocardiograms

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider