What is the clinical evidence from this study?

Study design: Review. Population: Coronary Artery Disease. Intervention: Physical activity vs. Physical inactivity.

What question did this study set out to answer?

To review the pathophysiological mechanisms and therapeutic benefits of regular physical activity in the primary and secondary prevention of coronary artery disease.

February 12, 2018Journal of the American Heart AssociationOpen Access

Physical Activity in the Prevention and Treatment of Coronary Artery Disease

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Key result

Regular physical activity prevents CAD by modulating risk factors, maintaining endothelial function, and attenuating progression.

Design

Review

Authors

EWEphraim B. WinzerTechnische Universität Dresden FWFelix WoitekInterventional Cardiology ALAxel LinkeInterventional Cardiology

Discussion

Member takes

Implication

Supports physical activity for CAD prevention; leaves open optimal dosing and adherence via prospective trials.

Key Points

To review the pathophysiological mechanisms and therapeutic benefits of regular physical activity in the primary and secondary prevention of coronary artery disease.
Narrative synthesis of clinical and experimental literature evaluating the impact of physical activity on cardiovascular risk factors and coronary artery disease progression.
Evaluation of vascular cellular mechanisms, focusing on endothelial nitric oxide synthase expression, circulating progenitor cell mobilization, and coronary angiogenesis.
Physical inactivity serves as an independent predictor of coronary artery disease, whereas regular exercise reduces incidence by boosting endothelial nitric oxide synthase expression, enhancing nitric oxide availability, and stimulating angiogenesis.
In secondary prevention, exercise training partially reverses endothelial alterations, raises the threshold for angina-free exertion, attenuates disease progression, and improves event-free survival.

Structured PICO

Exposure

Regular physical activity and exercise training

Regular physical activity is a potent strategy for both primary and secondary prevention of coronary artery disease, acting mechanistically through improved endothelial function and modulation of risk factors.

Cite This Study

Winzer et al. (2018) conducted a review in Coronary Artery Disease. Physical activity vs. Physical inactivity was evaluated. Regular physical activity is effective in the primary and secondary prevention of coronary artery disease by modulating risk factors, maintaining endothelial function, and attenuating disease progression.

synapsesocial.com/papers/6aa6916a014c9b816df4f4e1 https://doi.org/10.1161/jaha.117.007725

Topics

Coronary artery disease Coronary CT angiography Cardiovascular prevention

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Physical Activity in the Prevention and Treatment of Coronary Artery Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Physical Activity in the Prevention and Treatment of Coronary Artery Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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