Key result
Higher serum d-ROM correlates with greater carotid IMT in type II hypercholesterolemia.
Why the study?
Is increased oxidative stress associated with carotid intima-media thickness in patients with type II hypercholesterolemia?
Cross-Sectional (n=81)
Is increased oxidative stress associated with carotid intima-media thickness in patients with type II hypercholesterolemia?
Effect estimate: β = 0.27
p-value: p=<0.05
Increased oxidative stress, as measured by the d-ROM test, is independently associated with carotid atherosclerosis in patients with hypercholesterolemia.
May link oxidative stress to carotid atherosclerosis in hypercholesterolemia; hypothesis-generating and requires confirmation before clinical use.
OBJECTIVE: It was the aim of this study to investigate whether there is any relationship between oxidative stress, as assessed by the diacron reactive oxygen metabolite (d-ROM) test, and carotid atherosclerosis among hypercholesterolemic patients. SUBJECTS AND METHODS: A well-defined group of patients with type II hypercholesterolemia (n = 81, mean age 59 years) was studied to observe the correlation between the levels of serum d-ROMs and carotid artery intima-media thickness (IMT) using B-mode ultrasound, in relation to the traditional atherosclerotic risk factors (age, sex, smoking, body mass index, blood pressure, glucose and lipid panels). RESULTS: The mean level in low-density lipoprotein cholesterol (LDL-C) in this population was 4.45 mmol/l, d-ROMs were 323.2 Carr U, and IMT was 0.91 mm. A multiple regression analysis revealed a positive and significant correlation between IMT and d-ROMs (β = 0.27, p < 0.05), along with age and LDL-C. CONCLUSION: These results indicate that the increased oxidative stress levels using the d-ROM test, independent of aging and increased LDL-C levels, may be associated with carotid atherosclerosis even in hypercholesterolemic patients.
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Kotani et al. (2010) conducted a cross-sectional in Type II hypercholesterolemia (n=81). Oxidative stress (d-ROM levels) was evaluated on Carotid artery intima-media thickness (IMT) (β = 0.27, p=<0.05). Serum d-ROM levels were positively and significantly correlated with carotid intima-media thickness in patients with type II hypercholesterolemia (β = 0.27, p < 0.05).