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February 1, 2002The Journal of Physiology30 citationsOpen Access

Temperature effect on isometric tension is mediated by regulatory proteins tropomyosin and troponin in bovine myocardium

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Population

Bovine myocardium

Comparison

Actin filament-reconstituted myocardium without… vs Control bovine myocardium exposed to the same…

Design

Preclinical

Key result

In bovine myocardium, regulatory proteins tropomyosin and troponin augmented the temperature dependence of isometric tension, indicating they may modify the actomyosin interaction.

Authors

HFHideaki FujitaMKMasataka Kawai

Discussion

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Overview

Does not support clinical changes in myocardial contractility; leaves open regulatory protein effects on temperature sensitivity in human myocardium.

Structured PICO

P
Population
Bovine myocardium
I
Intervention
Actin filament-reconstituted myocardium without regulatory proteins (tropomyosin and troponin) exposed to temperature variations (5-40 degrees C)
C
Comparator
Control bovine myocardium (with regulatory proteins) exposed to the same temperature variations
O
Outcome
Effect of temperature on isometric tension and apparent rate constantssurrogate

Regulatory proteins tropomyosin and troponin augment the temperature dependence of isometric tension in bovine myocardium, suggesting they modify actomyosin interaction.

Cite This Study

Fujita et al. (2002) studied this question. Temperature variation and regulatory proteins (tropomyosin and troponin) vs. Myocardium without regulatory proteins was evaluated on Isometric tension and apparent rate constants. In bovine myocardium, regulatory proteins tropomyosin and troponin augmented the temperature dependence of isometric tension, indicating they may modify the actomyosin interaction.

synapsesocial.com/papers/6aa69a7ae46a8f6037922aa4https://doi.org/10.1113/jphysiol.2001.013220
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