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November 1, 2001The Journal of Physiology127 citationsOpen Access

Temperature dependence of active tension in mammalian (rabbit psoas) muscle fibres: effect of inorganic phosphate

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Population

Chemically skinned (0.5 % Brij) rabbit psoas muscle fibres

Comparison

Added inorganic phosphate at various temperatures vs Control with no added Pi

Design

Preclinical

Authors

MCM. E. CouplandEPE. PuchertKRK. W. Ranatunga

Discussion

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Overview

Pi-induced tension depression in mammalian fibers is temperature-sensitive; leaves open its relevance to human muscle at physiological temperatures.

Structured PICO

P
Population
Chemically skinned (0.5 % Brij) rabbit psoas muscle fibres
I
Intervention
Added inorganic phosphate (Pi, range 3-25 mM) at various temperatures (5-30 degrees C)
C
Comparator
Control with no added Pi (or Pi mop to reduce contaminating Pi to micromolar levels)
O
Outcome
Active tension (maximal Ca2+-activated tension)surrogate

Inorganic phosphate-induced active tension depression in mammalian muscle fibers is temperature-sensitive, becoming less marked at higher temperatures.

Cite This Study

Coupland et al. (2001) studied this question.

synapsesocial.com/papers/6a822e72f2e4e6540e2a4fa3https://doi.org/10.1111/j.1469-7793.2001.00879.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1An asymmetry in the phosphate dependence of tension transients induced by length perturbation in mammalian (rabbit psoas) muscle fibres2002 · 52 citations
  2. 2Phosphate increase during fatigue affects crossbridge kinetics in intact mouse muscle at physiological temperature2017 · 17 citations
  3. 3Endothermic force generation, temperature‐jump experiments and effects of increased [MgADP] in rabbit psoas muscle fibres2005 · 26 citations
  4. 4Effect of temperature on myosin phosphorylation in mouse skeletal muscle1990 · 137 citations
  5. 5Temperature effect on isometric tension is mediated by regulatory proteins tropomyosin and troponin in bovine myocardium2002 · 30 citations