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August 1, 2002The Journal of PhysiologyOpen Access

An asymmetry in the phosphate dependence of tension transients induced by length perturbation in mammalian (rabbit psoas) muscle fibres

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Population

Chemically skinned, maximally Ca-activated rabbit psoas muscle fibres at 10 degrees C

Comparison

Added inorganic phosphate (P) at concentrations… vs Control (no added P(i))

Design

Preclinical

Authors

KRK. W. RanatungaMCM. E. CouplandGMGM Mutungi

Discussion

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Overview

No immediate clinical implications in humans; leaves open Pi's strain-dependent effects on muscle force in disease models.

Structured PICO

P
Population
Chemically skinned (0.5 % Brij), maximally Ca(2+)-activated rabbit psoas muscle fibres at 10 degrees C (ionic strength 200 mM, pH 7.1)
I
Intervention
Added inorganic phosphate (P(i)) at concentrations ranging from 3 to 25 mM
C
Comparator
Control (no added P(i))
O
Outcome
Tension transients (initial tension recovery, phase 2a and 2b rates) induced by length perturbation (release and stretch)surrogate

Inorganic phosphate selectively accelerates tension decay after stretch but not tension rise after release in mammalian muscle fibers, indicating that Pi-sensitive force generation is sensitive to positive strain.

Cite This Study

Ranatunga et al. (2002) studied this question.

synapsesocial.com/papers/6a87c6a4350e059174ad31cchttps://doi.org/10.1113/jphysiol.2002.019471
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