Key result
Dipyridamole-echocardiography demonstrates 100% short-term reproducibility for detecting regional asynergy in angina patients.
Why the study?
Does the dipyridamole-echocardiography test have high short-term reproducibility for detecting regional asynergy in patients with angina?
Observational (n=87)
Does the dipyridamole-echocardiography test have high short-term reproducibility for detecting regional asynergy in patients with angina?
The dipyridamole-echocardiography test demonstrates excellent short-term reproducibility for detecting and timing regional asynergy in patients with angina.
Supports reproducibility in this angina cohort; prospective trials needed before clinical adoption.
The aim of this study was to assess the short-term reproducibility of dipyridamole-echocardiography test (DET) consisting of two-dimensional echo monitoring during dipyridamole infusion (up to 0.84 mg/kg in 10 min). The diagnostic end-point of the test is the detection of new onset or worsening regional asynergy. A group of 87 patients with rest and/or effort angina performed two DETS on two consecutive days. All 60 patients with a positive DET had a positive repeat test, and the 27 negative DETs were also negative on the following day. The timing of the asynergy was also very similar between the two tests, both in patients with angina on effort (r = .93, p less than 0.01) and at rest (r = .92, p less than 0.01). In conclusion, DET has a very high short-term reproducibility regarding the presence and timing of asynergy.
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Picano et al. (1987) conducted an observational in rest and/or effort angina (n=87). Dipyridamole-echocardiography test (DET) was evaluated on detection of new onset or worsening regional asynergy (p=<0.01). The dipyridamole-echocardiography test demonstrated 100% short-term reproducibility for detecting regional asynergy in patients with angina, with highly correlated timing between tests (P<0.01).
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