April 1, 1991Circulation
Inhibition of dipyridamole-induced ischemia by antianginal therapy in humans. Correlation with exercise electrocardiography.
Why the study?
Does antianginal therapy reduce dipyridamole-induced ischemia in patients with significant coronary artery disease?
Population
57 patients with angiographically assessed significant coronary artery disease
Comparison
Antianginal drugs vs Off treatment
Design
Cohort, random order for testing
Authors
Discussion
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Member takes
Implication
Antianginal therapy may blunt DET sensitivity; leaves open whether testing protocols require adjustment in treated CAD.
Structured PICO
Does antianginal therapy reduce dipyridamole-induced ischemia in patients with significant coronary artery disease?
P
Population
57 patients with angiographically assessed significant coronary artery disease (greater than 70% lumen reduction in at least one major coronary vessel)
I
Intervention
Antianginal drugs (beta-blockers, calcium antagonists and nitrates, alone or in various combinations)
C
Comparator
Off treatment
O
Outcome
Dipyridamole-induced ischemia (assessed by DET sensitivity, dipyridamole time, and wall motion score index) and exercise tolerance (assessed by exercise electrocardiography test)surrogate
Antianginal therapy significantly reduces dipyridamole-induced ischemia during echocardiography, and these changes correlate with improvements in exercise tolerance.
Cite This Study
Lattanzi et al. (1991) studied this question.