Key result
Congenital pulmonary valve stenosis is linked to increased LV and interventricular septal thickness.
Observational (n=18)
In patients with congenital pulmonary valve stenosis, left ventricular wall thickness is often increased, suggesting a direct interaction between the ventricles.
Should not yet change practice in congenital pulmonary valve stenosis; hypothesis-generating for ventricular interdependence and needs prospective confirmation.
The wall thickness of the left ventricle was measured in the hearts of 16 children and 2 adults who died of congenital pulmonary valve stenosis. A right-to-left shunt through a patent foramen ovale had existed in 12 cases and was excluded in the other 6. The thickness of the left ventricular wall and the interventricular septum was increased in the majority of hearts, especially in the older patients. There was a good correlation between wall thickness and histological appearance of the left ventricular myocardium; in 2 cases there was also evidence of left ventricular myocardial fibrosis. The coronary arteries appeared normal in all cases. A direct interaction between the ventricles was thought to be a possible mechanism.
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Harinck et al. (1977) conducted an observational in Congenital isolated pulmonary valve stenosis (n=18). Congenital pulmonary valve stenosis was evaluated on Left ventricular wall thickness and histological appearance. Congenital pulmonary valve stenosis was associated with increased thickness of the left ventricular wall and interventricular septum in the majority of 18 examined hearts.
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