What is the clinical evidence from this study?

Study design: Observational. Population: Cardiopulmonary bypass (n=24). Intervention: Nonpulsatile cardiopulmonary bypass vs. Before CPB. Primary outcome: Portal venous flow (PVF) as a percentage of systemic blood flow.

What does this research mean for the field?

Portal venous flow as a percentage of systemic blood flow is maintained during nonpulsatile hypothermic cardiopulmonary bypass. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate hepatic circulation and portal venous flow dynamics in patients undergoing nonpulsatile cardiopulmonary bypass.

July 1, 1995ASAIO Journal

Hepatic Circulation During Nonpulsatile Cardiopulmonary Bypass

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Key result

Nonpulsatile CPB maintains portal venous flow as a percentage of systemic blood flow.

n=24

Population

24 adult patients undergoing cardiopulmonary bypass

Design

Cohort

Follow-up

throughout cardiopulmonary bypass and post-bypass

Authors

TYTomoyuki YamadaOsaka Medical and Pharmaceutical University SNShinichi NomotoKyoto University MAMasaki AotaNikkei Business Publications (Japan)

Discussion

Member takes

Implication

Supports preserved splanchnic perfusion with nonpulsatile CPB; hypothesis-generating and requires prospective validation before practice change.

Key Points

To evaluate hepatic circulation and portal venous flow dynamics in patients undergoing nonpulsatile cardiopulmonary bypass.
Evaluated 24 adult surgical patients undergoing nonpulsatile hypothermic cardiopulmonary bypass at a flow rate of 2.4 L/min/m².
Measured portal venous flow velocity and cross-sectional area via color Doppler ultrasonography before, during (aortic clamping and rewarming), and after bypass.
Portal venous flow was maintained during bypass at 0.44 ± 0.13 L/min/m² during aortic cross-clamping and 0.54 ± 0.18 L/min/m² during rewarming.
The proportion of portal venous flow relative to systemic blood flow remained stable at 18.3 ± 9.3% before, 18.5 ± 5.5% during, and 17.4 ± 6.7% after cardiopulmonary bypass.

Study Design

Type

Observational (n=24)

Structured PICO

Population

24 adult patients undergoing nonpulsatile cardiopulmonary bypass to evaluate hepatic circulation.

Exposure

Nonpulsatile hypothermic cardiopulmonary bypass at a flow rate of 2.4 L/min/m2

Outcome

Portal venous flow (PVF) measured by color Doppler ultrasonography before, during, and after CPBsurrogate

Main Result

Absolute Event Rate: 18.5% vs 18.3%

Portal venous flow is maintained during nonpulsatile cardiopulmonary bypass at a flow rate of 2.4 L/min/m2 and remains proportional to systemic blood flow.

Cite This Study

Yamada et al. (1995) conducted an observational in Cardiopulmonary bypass (n=24). Nonpulsatile cardiopulmonary bypass vs. Before CPB was evaluated on Portal venous flow (PVF) as a percentage of systemic blood flow. Portal venous flow as a percentage of systemic blood flow was maintained during nonpulsatile cardiopulmonary bypass (18.5% during vs 18.3% before CPB).

synapsesocial.com/papers/6aa6a72f2f265d5e947f2833 https://doi.org/10.1097/00002480-199507000-00016

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Implication

Supports preserved splanchnic perfusion with nonpulsatile CPB; hypothesis-generating and requires prospective validation before practice change.

Hepatic Circulation During Nonpulsatile Cardiopulmonary Bypass

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Hepatic Circulation During Nonpulsatile Cardiopulmonary Bypass

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider