Key result
Human parechovirus presents in ~12% of young children with acute gastroenteritis, frequently co-occurring with rotavirus.
Why the study?
Human parechovirus is one of the major causes of acute gastroenteritis in children.
Cross-Sectional (n=250)
HPeV-1 is a significant cause of acute viral gastroenteritis in young children in Iran, often co-occurring with Rotavirus.
Supports parechovirus testing in young children with gastroenteritis; leaves open its independent role given frequent rotavirus co-infection.
Aim: Human parechovirus (HPeV) is one of the major causes of acute gastroenteritis in children. Materials & methods: Stool specimens (n = 250) were collected from children aged ≤3 years during 2018–2019. HPeV RNA was detected by reverse transcription-PCR and genotyping by VP1 gene, Rotavirus (RV) screened by ELISA. Results: HPeV was detected in 12% of the cases. The children under 6-months old (64.2%) were a sensitive group and HPeV was more prevalent during January–February (73.3%). The co-infection of HPeV with RV was 50%. All of the sequenced samples belong to the HPeV-1 genotype. Conclusion: HPeV-1 is one of the major causes of acute viral gastroenteritis in children and the co-infection of RV can be an additional infection in some cases.
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Mohammadi et al. (2020) conducted a cross-sectional in Acute gastroenteritis (n=250). Human parechovirus (HPeV) infection was evaluated on HPeV detection rate. Human parechovirus was detected in 12% of children aged ≤3 years with acute gastroenteritis, with 50% of these cases showing co-infection with Rotavirus.
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