Key result
Among 100 young infants hospitalized with sepsis-like illness, the frequency of human parechovirus genotype 1 was 5% and enterovirus was 38%.
Why the study?
Human parechoviruses and human enteroviruses frequently cause sepsis-like illness in infants younger than 3 months, prompting investigation of their frequency in Ahvaz city, Iran.
Cross-Sectional (n=100)
No
Human enteroviruses and parechoviruses are frequently detected in young infants presenting with sepsis-like illness in Iran, with enteroviruses being dominant.
Enteroviruses predominate over parechovirus in young Iranian infants with sepsis-like illness; hypothesis-generating for regional etiology and testing strategies.
BACKGROUND AND OBJECTIVES: Human parechoviruses (HPeV) and Human enteroviruses (EV) frequently cause a sepsis-like illness in young infants (younger than three months). Therefore, this study was conducted to determine the frequency of HPeV and EV among the young infants with clinical signs and symptoms of sepsis in Ahvaz city, Iran. MATERIALS AND METHODS: The blood specimens were collected from 100 (younger than 90 days hospitalized infants) including 54 (56.25%) males and 46 (43.75%) females with clinical signs and symptoms of sepsis-like disease. The RNA was extracted and tested for detection of VP1 region of HPeV and 5 UTR (Untranslated Region) of EV by RT-PCR. The sequences of positive of HPeV were further analyzed to determine HPeV genotyping. RESULTS: 5/100 (5%) of patients including 2/46 (2%) females and 3/54 (3%) males tested positive for HPeV (P=0.85). The analysis of 5 positive VP1 region of HPeV revealed the genotype 1. The analysis of sequencing and phylogenetic tree revealed that the isolated HPeVs were genotype 1. While 38/100 (38%) specimens including 16 (16%) females and 22 (22%) males were tested positive for EV (P=0.68). CONCLUSION: The frequency of HPeV genotype 1 was 5% among the young infants with sepsis. While frequency of EV was 38% among the young infants with sepsis. This study showed HPeV genotype 1 and EV are dominant in this region.
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Makvandi et al. (2021) conducted a cross-sectional in Sepsis-like illness (n=100). Human parechovirus (HPeV) and Enterovirus (EV) infection was evaluated on Frequency of HPeV and EV infection. Among 100 young infants hospitalized with sepsis-like illness, the frequency of human parechovirus genotype 1 was 5% and enterovirus was 38%.
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