Key result
Flow-induced pressure on endothelial cells matches shear stress magnitude, influencing cell shape and alignment.
Population
Individual human endothelial cells (ECs)
Design
Preclinical
Authors
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Should not yet inform clinical models of flow-mediated remodeling; leaves open pressure's role in endothelial alignment in vivo.
Flow-induced pressure on endothelial cells is of the same magnitude as shear stress, suggesting that ECs reshape and realign to minimize drag and shear-induced torque.
Voorhees et al. (2007) studied this question. Flow-induced pressure was evaluated on Three-dimensional shear stress and pressure distributions over endothelial cells. Flow-induced pressure on human endothelial cells is of the same magnitude as shear stress, with maximum magnitudes at the toe and heel of the cells, influencing cell shape and alignment.
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