Key result
Baseline adenylyl cyclase activity directly correlates with control coronary flow in the canine left ventricle.
Population
8 anaesthetized open-chest dogs
Comparison
Sympathetic stimulation and forskolin stimulation vs Control conditions
Design
Preclinical
Authors
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Does not inform clinical coronary flow management; hypothesis-generating for adenylyl cyclase in canine myocardial perfusion heterogeneity.
Effect estimate: r = 0.47
p-value: p=< 0.0001
This preclinical study demonstrates a direct linear relationship between local myocardial adenylyl cyclase activity and coronary blood flow heterogeneity in the canine heart.
Rodríguez et al. (1993) studied this question. Sympathetic stimulation vs. Control conditions was evaluated on Relationship between adenylyl cyclase activity and coronary flow (r = 0.47, p=< 0.0001). In canine left ventricle, there was a direct linear relationship between baseline adenylyl cyclase activity and control coronary flow (r=0.47, P<0.0001).
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