Key result
Isoproterenol stimulation resulted in a significant correlation between normalized stimulated coronary blood flow and myocardial cAMP levels (r = 0.48, p < 0.0001).
Why the study?
Does isoproterenol infusion alter the relationship between regional cyclic AMP and local coronary blood flow in the canine myocardium?
Population
14 anesthetized open-chest dogs
Comparison
Isoproterenol infusion (0.5 micrograms/kg/min) vs Control conditions (no isoproterenol)
Design
Preclinical
Authors
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Preclinical correlation in canines; leaves open whether cAMP modulates regional coronary flow in humans.
Does isoproterenol infusion alter the relationship between regional cyclic AMP and local coronary blood flow in the canine myocardium?
Effect estimate: r = 0.48
p-value: p=< 0.0001
Isoproterenol stimulation induces a significant correlation between regional myocardial cAMP heterogeneity and local coronary blood flow in the canine heart.
Ramirez et al. (2008) studied Myocardial cAMP and coronary blood flow heterogeneity (n=14). Isoproterenol vs. Control was evaluated on Correlation between local blood flow and local cAMP (r = 0.48, p=< 0.0001). Isoproterenol stimulation resulted in a significant correlation between normalized stimulated coronary blood flow and myocardial cAMP levels (r = 0.48, p < 0.0001).
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