Population
Patients with severe end-stage pulmonary and pulmonary-vascular disease who have undergone lung or…
Design
Review
Key result
Lung transplantation improves maximal exercise capacity to 40 to 60% of predicted values, though it remains below normal primarily due to peripheral skeletal muscle impairment.
Authors
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May warrant muscle rehabilitation post-lung transplant; leaves open optimal interventions in prospective trials.
Exercise limitation after lung transplantation is primarily driven by peripheral skeletal muscle dysfunction, exacerbated by pretransplant injury and immunosuppressive therapy, rather than ventilatory constraints.
Slater et al. (2002) conducted a review in severe end-stage pulmonary and pulmonary-vascular disease. Lung transplantation was evaluated on maximal exercise capacity (VO2 peak). Lung transplantation improves maximal exercise capacity to 40 to 60% of predicted values, though it remains below normal primarily due to peripheral skeletal muscle impairment.
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