Key result
Post-bypass AF is linked to ~38% higher 48-hour BNP levels.
Why the study?
Is elevated brain natriuretic peptide associated with the development of atrial fibrillation following coronary artery bypass surgery in patients with preserved left ventricular function?
Cohort (n=133)
Is elevated brain natriuretic peptide associated with the development of atrial fibrillation following coronary artery bypass surgery in patients with preserved left ventricular function?
Absolute Event Rate: 440% vs 319%
p-value: p=0.001
Elevated brain natriuretic peptide levels at 48 hours post-CABG are associated with the development of late atrial fibrillation, suggesting a role for atrial stretch in the pathogenesis of this arrhythmia.
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Elevated 48-hour BNP was associated with post-CABG AF; supports atrial stretch hypothesis but should not change practice.
J. Cosgrave (2006) conducted a cohort in Coronary artery bypass surgery (n=133). Atrial fibrillation vs. No atrial fibrillation was evaluated on Median 48-hour brain natriuretic peptide levels (pg/ml) (p=0.001). Patients who developed atrial fibrillation following bypass surgery had significantly higher median 48-hour brain natriuretic peptide levels than those without the arrhythmia (440 vs 319 pg/ml; P=0.001).
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