What is the clinical evidence from this study?

Population: Fetal mice cardiovascular development. Intervention: Noninvasive ultrasound imaging. Primary outcome: Feasibility of structural and functional analysis of the developing heart.

What does this research mean for the field?

High-frequency noninvasive ultrasound imaging enables structural and functional evaluation of the developing mouse cardiovascular system from gestation days E12.5 to E18.5. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 1, 2003Birth Defects Research Part C Embryo Today Reviews

Noninvasive phenotypic analysis of cardiovascular structure and function in fetal mice using ultrasound

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Key result

Noninvasive ultrasound successfully enables structural and functional analysis of the developing mouse fetal heart.

Why the study?

Can ultrasound imaging be used for noninvasive structural and functional analysis of the developing mouse fetal heart?

Population

Mouse fetuses spanning gestation day 12.5 to 18.5 (E12.5-E18.5)

Design

Preclinical

Authors

LLLinda LeatherburyChildren's National QYQing YuUniversity School CLCecilia W. LoUniversity of Pittsburgh

Discussion

Member takes

Implication

Facilitates high-throughput phenotyping of mouse fetal hearts; extends developmental cardiology tools while leaving human translation open.

Structured PICO

Can ultrasound imaging be used for noninvasive structural and functional analysis of the developing mouse fetal heart?

Population

Mouse fetuses spanning gestation day 12.5 to 18.5 evaluated for cardiovascular structure and function using noninvasive ultrasound.

Intervention

Noninvasive ultrasound imaging using an Acuson/Siemens Sequoia ultrasound scanner equipped with a single-pulse CHIRP Coded Excitation program and a high-frequency linear array transducer

Outcome

Feasibility of structural and functional analysis of the developing mammalian heartsurrogate

Noninvasive cardiovascular ultrasonic evaluation is feasible for structural and functional analysis of developing mouse fetuses, making it suitable for high-throughput screening of mutagenized mice.

Cite This Study

Leatherbury et al. (2003) studied Fetal mice cardiovascular development. Noninvasive ultrasound imaging was evaluated on Feasibility of structural and functional analysis of the developing heart. Noninvasive ultrasound imaging successfully enabled structural and functional analysis of the developing mouse fetal heart from gestation day 12.5 to 18.5.

synapsesocial.com/papers/6aa6c8d1c34c6f6bfa64e85a https://doi.org/10.1002/bdrc.10005

Topics

Echocardiography Congenital heart disease adults

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Implication

Facilitates high-throughput phenotyping of mouse fetal hearts; extends developmental cardiology tools while leaving human translation open.

Noninvasive phenotypic analysis of cardiovascular structure and function in fetal mice using ultrasound

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Noninvasive phenotypic analysis of cardiovascular structure and function in fetal mice using ultrasound

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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