Key result
High-frequency 40-MHz TTE safely and reliably delineates cardiac anatomy and physiology in newborn mice.
Observational
High-frequency (40-MHz) transthoracic echocardiography is a safe and reliable method for assessing cardiac anatomy and physiology in newborn mice, providing normative values for future genetic and congenital heart disease research.
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May facilitate phenotyping in newborn mouse models; leaves open translation to human neonates and disease states.
The mouse has become a powerful genetic tool for studying genes involved in cardiac development and congenital heart disease. Many of the most severe congenital heart defects are ductal-dependent, resulting in neonatal lethality. Recent advances in ultrasound technology provide an opportunity for the use of high-frequency transducers to characterize the cardiac anatomy and physiology of the newborn mouse. In this study, we define limited normative values for cardiac structure and function in the C57BL newborn mouse. Specifically, we define normal values for 19 indices derived from standard echocardiographic views. This study demonstrates that transthoracic echocardiography using a 40-MHz high-frequency transducer is a safe and reliable noninvasive modality for the delineation of cardiac anatomy and physiology in the newborn mouse.
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Bose et al. (2007) conducted an observational in Normal cardiac structure and function. Transthoracic echocardiography using a 40-MHz high-frequency transducer was evaluated on Normal values for 19 indices derived from standard echocardiographic views. Transthoracic echocardiography using a 40-MHz high-frequency transducer is a safe and reliable noninvasive modality for the delineation of cardiac anatomy and physiology in the newborn mouse.
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