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January 1, 1989The Annals of Thoracic SurgeryOpen Access

LVAS stabilizes refractory cardiogenic shock, bridging ~50% of patients to cardiac transplantation.

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Why the study?

Does an implantable left ventricular assist system (LVAS) provide effective hemodynamic support as a bridge to cardiac transplantation in patients with refractory cardiogenic shock?

Population

20 patients who were hemodynamically unstable or in refractory cardiogenic shock, mean age 44.9 years…

Design

Case_series

Follow-up

up to 90 days (mean, 22.7 days)

Key result

An implantable left ventricular assist system provided hemodynamic stabilization in all 20 patients with refractory cardiogenic shock, serving as a successful bridge to transplantation in 10 patients.

Authors

PPPeer M. PortnerPOPhilip E. OyerDPD. Glenn Pennington

Discussion

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Overview

May support LVAS stabilization in refractory shock; hypothesis-generating pending controlled trials on safety and outcomes.

Structured PICO

Does an implantable left ventricular assist system (LVAS) provide effective hemodynamic support as a bridge to cardiac transplantation in patients with refractory cardiogenic shock?

P
Population
20 patients (mean age 44.9 years, 20% female) who were hemodynamically unstable or in refractory cardiogenic shock received an implantable left ventricular assist system for up to 90 days.
I
Intervention
Implantable left ventricular assist system (LVAS) utilizing an electromechanically driven dual pusher-plate blood pump, connected between the left ventricular apex and ascending aorta, for up to 90 days (mean 22.7 days).
O
Outcome
Hemodynamic stabilization and successful bridge to orthotopic cardiac transplantationhard clinical

An implantable LVAS can effectively stabilize patients in refractory cardiogenic shock and serve as a bridge to cardiac transplantation, though bleeding complications are common.

Cite This Study

Portner et al. (1989) studied Hemodynamically unstable or refractory cardiogenic shock (n=20). Implantable left ventricular assist system (LVAS) was evaluated on Orthotopic cardiac transplantation. An implantable left ventricular assist system provided hemodynamic stabilization in all 20 patients with refractory cardiogenic shock, serving as a successful bridge to transplantation in 10 patients.

synapsesocial.com/papers/6aa6d64322b05484233978c7https://doi.org/10.1016/0003-4975(89)90256-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Implantable Left Ventricular Assist Systems (LVAS): Recent Results. A Report from a Series of Meetings Sponsored by the Study Group on Advanced Heart Failure of the Working Group on Heart Failure2000 · 6 citations
  2. 2Implantable Left Ventricular Assist System2009 · 11 citations
  3. 3Left Ventricular Assist Devices — Reasons to be Enthusiastic1999 · 8 citations
  4. 4Recovery of Cardiac Function by Long-Term Left Ventricular Support in Patients With End-Stage Cardiomyopathy1998 · 33 citations
  5. 5Left Ventricle Assist Systems: A Possible Alternative to Heart Transplantation for Heart Failure Patients? Patient Selection, Techniques and Benefit1999 · 7 citations