Odds Ratio: 1.31 (95% CI 1.21–1.42)
p-value: p=4.1×10^-11
Large-scale genome-wide association studies have identified the ATP2B1 gene as a genetic risk factor for hypertension across different ethnicities.
May support refined hypertension genetic screening; leaves open paradoxical CAD links for causal validation.
hypertension; however, the contribution of each single-nucleotide pleomorphism (SNP) was not very powerful in its association with hypertension or hypertension-related diseases.With the technical progress in genetic analyses, large-scale genomewide association studies (GWAS) have been successful in identifying genes that contribute to common diseases and phenotypes.A GWAS of hypertension-related phenotypes in a Japanese population has been conducted, and the ATPase, Ca 2+ transporting, plasma membrane 1 gene (ATP2B1) was successfully identified as a gene responsible for hypertension not only in Japanese patients but also Caucasians. 9
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Hironori Nakagami (2015) conducted an editorial in Hypertension and Coronary Artery Disease (n=17,785). ATP2B1 SNP rs11105378l vs. Reference allele was evaluated on Hypertension (OR 1.31, 95% CI 1.21-1.42, p=4.1×10^-11).
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