Key result
PCOS linked to ~30% higher absolute obesity prevalence alongside increased prediabetes and elevated LDL.
Why the study?
Polycystic ovarian syndrome is associated with an increased risk of cardiometabolic diseases, prompting evaluation of cardiovascular risk factor prevalence compared to age-matched controls.
Does polycystic ovarian syndrome increase the prevalence of cardiovascular risk factors compared to age-matched controls?
Case-Control (n=80)
Yes
Does polycystic ovarian syndrome increase the prevalence of cardiovascular risk factors compared to age-matched controls?
Absolute Event Rate: 42.5% vs 12.5%
p-value: p=0.005
Women with PCOS have a higher prevalence of cardiometabolic risk factors including obesity, diabetes, and dyslipidemia, highlighting the need for cardiovascular risk screening in this population.
Background: Polycystic ovarian syndrome is a common endocrine disorder of women during reproductive age, associated with increased risk of cardiometabolic diseases. Objective: To assess the prevalence of cardiovascular risk factors in patients with the polycystic ovarian syndrome in comparison to age-matched control. Patients and Methods: This cross-sectional studyis conducted in Erbil city fromSeptember 2020 to January 2021. It included 40 cases of polycystic ovarian syndrome and 40 cases of healthy controls. Participants underwent detailed history, physical examination. Laboratory investigations (blood sugar, lipid profile, serum testosterone and serum prolactin) and pelvic ultrasound were done for them. Data analysis was performed by Statistical Package for Social Sciences (SPSS) version 25. Results: Women with the polycystic ovarian syndrome have a higher proportion to obesity, abnormal blood sugar, and dyslipidemia, they have higher rate of menstrual irregularity, hyperandrogenic state and hirsutism, than age-matched control. The risk for hypertension remains the same for both PCOS and the control group. Conclusion: The proportion of obesity, diabetes, and dyslipidemia is higher in Polycystic ovarian syndrome than the control group.
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Saleh et al. (2021) conducted a case-control in Polycystic ovarian syndrome (PCOS) (n=80). Polycystic ovarian syndrome vs. Age-matched healthy controls without PCOS was evaluated on Obesity (p=0.005). Polycystic ovarian syndrome was associated with a significantly higher prevalence of obesity (42.5% vs 12.5%, p=0.005), prediabetes (25% vs 2.5%, p=0.007), and elevated LDL cholesterol compared to healthy controls.
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