Key result
Low-dose sotalol is associated with ~62% VT non-inducibility during programmed electrical stimulation.
Why the study?
Does oral sotalol reduce the inducibility of ventricular tachycardia in patients with sustained monomorphic ventricular tachycardia or ventricular fibrillation?
Observational (n=26)
Does oral sotalol reduce the inducibility of ventricular tachycardia in patients with sustained monomorphic ventricular tachycardia or ventricular fibrillation?
Low-dose oral sotalol rendered 62% of patients with inducible VT/VF non-inducible and showed 82% efficacy in preventing recurrences over 13 months, though with notable proarrhythmic risk.
No takes yet. Share an insight, caveat, or question.
Should not yet change practice for VT/VF; hypothesis-generating and requires randomized confirmation.
Jordaens et al. (1989) conducted an observational in sustained monomorphic ventricular tachycardia or ventricular fibrillation and inducible ventricular tachycardia (n=26). oral sotalol vs. baseline was evaluated on non-inducibility of ventricular tachycardia. Low-dose oral sotalol rendered 62% of patients non-inducible during programmed electrical stimulation, with an 82% efficacy against recurrences over a mean follow-up of 13 months.
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