Key result
Oral sotalol rendered ventricular tachycardia non-inducible in 60% of patients, while 23% manifested at least one new morphology during electropharmacological testing.
Why the study?
Does oral sotalol alter induced ventricular tachycardia morphology during programmed stimulation in patients with coronary artery disease and sustained monomorphic ventricular tachycardia?
Population
90 consecutive patients with coronary artery disease and sustained monomorphic ventricular tachycardia
Comparison
Oral sotalol vs Baseline (pre-sotalol) state
Design
Cohort
Authors
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Sotalol achieved non-inducibility in 60% of CAD patients with VT; leaves open whether baseline morphology predicts response unlike class I agents.
Observational (n=90)
Does oral sotalol alter induced ventricular tachycardia morphology during programmed stimulation in patients with coronary artery disease and sustained monomorphic ventricular tachycardia?
Oral sotalol can induce new ventricular tachycardia morphologies during programmed stimulation, suggesting a potential proarrhythmic effect that may have implications for ICD programming and ablation procedures.
Reisinger et al. (1995) conducted an observational in Coronary artery disease and sustained monomorphic ventricular tachycardia (n=90). Oral sotalol was evaluated on Non-inducibility of ventricular tachycardia. Oral sotalol rendered ventricular tachycardia non-inducible in 60% of patients, while 23% manifested at least one new morphology during electropharmacological testing.
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