Key result
Family history of hypertension is linked to genetic predisposition for ischemic and subarachnoid strokes.
Why the study?
Hypertension is an independent risk factor for stroke and both have genetic predispositions, but the genetic relationship between hypertension and stroke in first-degree relatives remains unclear.
Does a genetic predisposition to a family history of hypertension increase the risk of stroke?
Observational
Does a genetic predisposition to a family history of hypertension increase the risk of stroke?
This Mendelian randomization study provides evidence that a family history of hypertension has a shared genetic basis with various types of stroke.
Supports shared genetic basis of family hypertension history with stroke subtypes; hypothesis-generating for risk models and requires validation before clinical use.
BACKGROUND: Clinical observational study demonstrated that hypertension is an independent risk factor for stroke. Furthermore, both hypertension and stroke exhibit genetic predispositions. However, the genetic relationship between hypertension and stroke in first-degree relatives remains unclear. METHOD: The Genetic effects were validated using an across-Mendelian randomization (MR) approach. The Genome-Wide Association Study summary data used in this study were obtained from a publicly available platform. The primary MR effect employed was inverse-variance weighted (IVW), and the other analysis methods included MR-Egger, weighted median, simple mode, and weighted mode. Prior to MR analysis, tests for MR_PRESSO, pleiotropy, and heterogeneity were conducted. RESULT: The presence of family history of hypertension significantly contributed to the genetic predisposition to various types of stroke, including ischemic stroke, subarachnoid hemorrhage, lacunar stroke, cardioembolic ischemic stroke, small vessel ischemic stroke, and large artery atherosclerosis-related ischemic stroke. CONCLUSION: Briefly, hypertension in first-degree relatives has a genetic impact on the risk of stroke development. Shared genetic factors may exist between hypertension and stroke.
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Chi et al. (2024) conducted an observational in Stroke. Family history of hypertension was evaluated on Risk of various types of stroke. A family history of hypertension significantly contributed to the genetic predisposition to various types of stroke, including ischemic stroke and subarachnoid hemorrhage.
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