Why the study?
Does being a first-degree relative of a hypertensive proband increase the risk of stroke compared to nonbiological relatives?
Population
354 hypertensive probands ascertained in a clinic-based setting, their 1427 first-degree relatives, and 239…
Comparison
First-degree relative of a hypertensive proband vs Spouse of a hypertensive proband
Design
Cohort
Authors
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Suggests familial stroke predisposition beyond hypertension; hypothesis-generating for genetic risk assessment in relatives.
Does being a first-degree relative of a hypertensive proband increase the risk of stroke compared to nonbiological relatives?
A higher occurrence of hypertension and stroke in parents of hypertensive probands compared with spouses suggests shared genetic factors predisposing to these conditions, with a familial component to stroke independent of hypertension.
Nicolaou et al. (2000) studied this question.