July 1, 2001Psychophysiology

Modulation of the human nociceptive flexion reflex across the cardiac cycle

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Normotensive (n=40). Intervention: Systole (maximal arterial baroreceptor stimulation) vs. Diastole (minimal arterial baroreceptor stimulation). Primary outcome: Nociceptive flexion reflex (NFR) indexed by electromyographic (EMG) activity.

Q: What does this research mean for the field?

Nociceptive flexion reflex responses are significantly attenuated during systole compared to diastole, supporting the arterial baroreflex mechanism of hypertensive hypoalgesia. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

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Key result

Systole is linked to attenuated nociceptive reflexes versus diastole, supporting baroreflex-mediated hypertensive hypoalgesia.

n=40

Why the study?

Does arterial baroreceptor stimulation during systole reduce nociceptive flexion reflex responses compared to diastole in normotensive adults?

Population

40 normotensive adults

Comparison

Electrocutaneous stimulation of the sural nerve… vs Electrocutaneous stimulation of the sural nerve…

Design

Other

Authors

LELouisa EdwardsUniversity of British Columbia Hospital CRChristopher RingPreventive Cardiology DMDavid McIntyreQueen's University Belfast

Discussion

Member takes

Implication

Baroreflex-mediated nociceptive attenuation may inform hypertensive hypoalgesia mechanisms; leaves open clinical translation and requires prospective trials.

Study Design

Type

Observational (n=40)

Structured PICO

Does arterial baroreceptor stimulation during systole reduce nociceptive flexion reflex responses compared to diastole in normotensive adults?

Population

40 normotensive adults assessed for nociceptive flexion reflex across the cardiac cycle.

Exposure

Electrocutaneous stimulation of the sural nerve during systole (maximal arterial baroreceptor stimulation)

Comparator

Electrocutaneous stimulation of the sural nerve during diastole (minimal arterial baroreceptor stimulation)

Outcome

Nociceptive flexion reflex (NFR) response indexed by electromyographic (EMG) activity in the biceps femorissurrogate

Natural stimulation of baroreceptors by blood pressure changes during systole dampens nociception, supporting the arterial baroreflex mechanism of hypertensive hypoalgesia.

Cite This Study

Edwards et al. (2001) conducted an observational in Normotensive (n=40). Systole (maximal arterial baroreceptor stimulation) vs. Diastole (minimal arterial baroreceptor stimulation) was evaluated on Nociceptive flexion reflex (NFR) indexed by electromyographic (EMG) activity. Nociceptive flexion reflex responses were significantly attenuated during systole compared to diastole, supporting the arterial baroreflex mechanism of hypertensive hypoalgesia.

synapsesocial.com/papers/6aa703d8bb64cafef81b355e https://doi.org/10.1017/s0048577201001202

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Implication

Baroreflex-mediated nociceptive attenuation may inform hypertensive hypoalgesia mechanisms; leaves open clinical translation and requires prospective trials.

Modulation of the human nociceptive flexion reflex across the cardiac cycle

Discussion

Member takes

Implication

Study Design

Structured PICO

Cite This Study

Modulation of the human nociceptive flexion reflex across the cardiac cycle

Discussion

Member takes

Implication

Study Design

Structured PICO

Cite This Study

Also Consider

Also Consider