Key result
Interferon treatment induces target mRNAs ~15-fold in Ehrlich ascites tumor cells, demonstrating murine gene linkage.
Identifies a close linkage between two interferon-activatable murine genes (202 and 203) that are transcribed in the same direction.
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No immediate clinical implications from murine model; leaves open human homologs and antiviral relevance.
Previously we have identified a mouse genomic clone (clone 5) which specifies the 5' flanking region and the 5' terminal exon of an interferon-activatable gene (202 gene). Here, we show that about 5 kb upstream from this flanking region in clone 5 there occurs a 3' terminal region of a second interferon-activatable gene (203 gene). The two genes are transcribed in the same direction. Segments from the 203 gene can be hybridized to a set of five interferon-inducible RNAs. The 203 mRNAs are induced about 15-fold in interferon-treated Ehrlich ascites tumor cells.
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Engel et al. (1988) studied this question. Interferon was evaluated on 203 mRNA induction (15-fold induction). Interferon treatment induced 203 mRNAs about 15-fold in Ehrlich ascites tumor cells, demonstrating close linkage of two interferon-activatable murine genes.
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